Multiple Molecular Targets of Sensitizers in Tumor Necrosis Factor (TNF)-Related Apoptosis-Inducing Ligand (TRAIL/Apo2L)-Mediated Apoptosis
نویسندگان
چکیده
منابع مشابه
Tumor necrosis factor-related apoptosis-inducing ligand-mediated apoptosis in androgen-independent prostate cancer cells.
Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) has been reported to induce cell death in a variety of transformed cells but spared the normal cells. In this study, we examined its potential against advanced prostate cancer cells. Treatment of PC-3 and DU145 cells with TRAIL caused a rapid apoptotic cell death, whereas tumor necrosis factor-alpha (TNF-alpha) is ineffective unles...
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Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) has been reported to induce cell death in a variety of transformed cells but spared the normal cells. In this study, we examined its potential against advanced prostate cancer cells. Treatment of PC-3 and DU145 cells with TRAIL caused a rapid apoptotic cell death, whereas tumor necrosis factor-a (TNF-a) is ineffective unless in the...
متن کاملBerberine enhances tumor necrosis factor-related apoptosis-inducing ligand-mediated apoptosis in breast cancer
Berberine (BBR) has been used for the treatment of bacterial and fungal infections and also for cancer-associated symptoms such as diarrhea. Furthermore, it has been reported that BBR may have direct antitumor effects. Although evidence supports the theory that tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) is a promising candidate for treating cancer, its usage may be li...
متن کاملEffect of Arsenic Trioxide in TRAIL (Tumor Necrosis Factor-related Apoptosis Inducing Ligand)-Mediated Apoptosis in Multiple Myeloma Cell Lines.
PURPOSE The potential therapeutic application of the tumor necrosis factor-related apoptosis-inducing ligand (TRAIL), in the treatment of multiple myeloma (MM), was recently proposed. However, there have been some problems with the use of TRAIL, due to the appearance of TRAIL-resistant cells in MM. The effect of arsenic trioxide (As2O3) on the rate of apoptosis induced by TRAIL was evaluated in...
متن کاملtumor necrosis factor-related apoptosis-inducing ligand gene polymorphisms and hepatitis b virus infection
conclusions according to our result, 1525g/a and 1595c/t were in strong linkage disequilibrium and the polymorphisms of the trail gene in the 3’ utr region were not associated with the outcome of hbv infection. results our data showed that genotypes 1525g/a and 1595c/t were in complete linkage disequilibrium and the genotype frequencies at the two positions were the same. no significant differe...
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ژورنال
عنوان ژورنال: Journal of Life Science
سال: 2011
ISSN: 1225-9918
DOI: 10.5352/jls.2011.21.11.1641